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![]() ![]() One of the best understood lncRNAs functioning in development, HOTAIR, is located within the HoxC gene cluster on chromosome 12, and represses the expression of genes in the HoxD gene cluster on chromosome 2. LncRNAs could cooperate with DNA, other RNAs or proteins to function in cell differentiation, development to diseases. With their number approaching 10 thousand in the human genome, lncRNAs have been shown to have diverse activities, ranging from recruiting chromatin remodeling complexes to transcriptional regulation and post transcriptional processing of RNAs. Based on the size of their transcripts, noncoding RNAs (ncRNAs) are classified into small noncoding RNAs (length 200 nt). The remainder, collectively referred to as noncoding RNAs, are one of the most intensely investigated subjects in almost all areas of biomedical science. We found that differentially expressed lncRNAs may regulate the expression of many cellular protein-coding genes involved in pathways from native immunity to neuronal development, thus revealing important roles of lncRNAs in the regulation of host transcriptional programs in HSV-1 infected human cells.Īpproximately 70 % of the human genome is transcribed, but less than 2 % of which encodes proteins. Gene Ontology and Pathway enrichment analyses revealed potential lncRNA targets, including genes in chromatin assembly, genes in neuronal development and neurodegenerative diseases and genes in the immune response, such as Toll-like receptor signaling and RIG-I-like receptor signaling pathways. We detected 208 annotated and 206 novel differentially expressed lncRNAs. Here we analyzed HSV-1 infection induced, differentially expressed lncRNAs and predicted their target genes. Based on correlations of expression patterns of differentially expressed protein-coding genes and lncRNAs, we predicted that these lncRNAs may regulate, either in cis or in trans, the expression of many cellular protein-coding genes. We analyzed differentially expressed lncRNAs and their potential targets from RNA-seq data in HSV-1 infected human foreskin fibroblast (HFF) cells. However, how genome wide lncRNAs expressions are affected by the infection and how lncRNAs expression relates to protein coding gene expression have not been analyzed. HSV-1 productive infection leads to profound changes in the host cells, including the host transcriptome. Herpes Simplex Virus type I (HSV-1) latently infects over 80 % of the population, its reactivation from latency usually results in productive infections in human epithelial cells, and is responsible for the common cold sores and genital Herpes. One of the most important functions of long noncoding RNAs (lncRNAs) is to control protein coding gene transcription by acting locally in cis, or remotely in trans. ![]() ![]() That starts with its design, as it has a built-in stand that lets you angle it on surfaces without any sort of case, or even hang it off things – hence the Yoga name. The Lenovo Yoga Tab 13 is a really interesting tablet – one that goes well beyond just being a smartphone with a bigger screen. Read the full Samsung Galaxy Tab S8 Ultra review But for Android fans who want the best available option and aren’t on a budget, this is the tablet to buy. ![]() But that last point is a big part of why the Tab S8 Ultra doesn’t quite match the best that Apple has to offer, because Android is a slightly unwieldy tablet operating system.Ĭouple that with the slate itself being large and heavy enough to not be as portable as you might want your tablet to be, and Apple edges the win. So in many ways it really is an even bigger iPad Pro – just one that runs Android. You can also buy a keyboard folio for the Samsung Galaxy Tab S8 Ultra, and it has great speakers and plenty of storage. The Samsung Galaxy Tab S8 Ultra can also more or less match Apple’s best tablet in a lot of ways, including power, thanks to a top-end Snapdragon 8 Gen 1 chipset, and cameras, with both slates sporting a handy 12MP ultra-wide camera on the front. ![]() While we thought that we'd find the giant screen overwhelming, it's actually great, whether you're using it for art or just watching movies. Samsung’s tablet has an even bigger 14.6-inch screen, and it comes with an S Pen stylus in the box – while with the iPad you have to buy an Apple Pencil separately. ![]() With the Samsung Galaxy Tab S8 Ultra, Samsung isn’t just aiming to compete with the iPad Pro 12.9 (2021), it’s aiming to top Apple’s slate. ![]() ![]() ![]() ![]() ![]() It can automate Advanced Shipping Notices and the subsequent confirmation of despatched orders with a logistics company, facilitate the creation of Bills of Materials by integrating an Enterprise Resource Planning (ERP) solution to a CAD solution or even automate the issuing of works orders to machinery on the shop floor, streamlining processes and ensuring that machinery is working at full potential. It fills the integration gap that many manufacturing businesses are missing, and can empower people to automate without the need for any technical skills.” DataSwitchĭataSwitch harnesses the Internet of Things to integrate front-office and back-office management and production systems, to help manufacturing businesses better manage, utilise, and analyse the data available to them. “DataSwitch solves this problem by enabling businesses to communicate and integrate various business systems, setting up unique work streams from one single source. The result is a number of disparate systems that automate certain areas of the supply chain, but which do not communicate or integrate with each other for complete automation. The problem is that many businesses are doing this at the point of need, rather than stepping back and looking at their overall technology strategy. She commented: “There is a lot of technology already implemented into manufacturing and businesses are generally good at recognising there is a need for new systems, and implementing them. The solution, called DataSwitch, has been made available at a time when the Institute of Mechanical Engineers has revealed that only eight per cent of manufacturers have a significant understanding of Industry 4.0 processes, and 64% of these are looking towards automation software to improve production processes.Ĭathie Hall, Managing Director of K3 Syspro, said that the problem hampering Industry 4.0 acceleration is not the adoption of technology in manufacturing, but the integration and communication between different business systems, a problem which DataSwitch aims to solve. K3 Syspro has released to the market a purpose built systems integration and data manipulation tool, which enables businesses to become more efficient through automating processes. In this article, we look at K3 Syspro's breakthrough new DataSwitch technology, which promises to harness the Internet of Things for manufacturers to get the best possible results.Ī manufacturing technology expert has solved many of the integration problems currently affecting the sector in its adoption of Industry 4.0. PIF finds out more about the manufacturing technology expert who might just have solved many of the integration problems currently affecting the sector in its adoption of Industry 4.0. ![]() ![]() ![]() ![]() The Tomb Kings top them all, however, as they use their Skull Catapults to throw blazing skeleton heads of energy, as well as agonized souls!.Besides their poisonous darts, the Lizardmen fire beams of solar energy, from stone cannons atop dinosaurs!.The Skaven fully embrace this trope, utilizing a wide variety of different projectiles, including but not limited to condensed warp lightning and poison gas grenades. ![]() Total War: Warhammer II contains examples of the following: Many tropes that apply here also apply to Warhammer, and vice versa.Ī sequel titled Total War: Warhammer III was released in 2022, which features the Tzardom of Kislev, the Empire of Grand Cathay, the Daemons of Chaos (split among Khorne, Tzeentch, Nurgle, Slaanesh and Chaos Undivided), and the Ogre Kingdoms. Two paid expansions added the Tomb Kings and the Vampire Coast to the setting, while other expansions and free add-ons have re-introduced special subfactions of the Empire of Man, the Kingdom of Bretonnia, the Greenskins, the Wood Elves, the Beastmen, and the Dwarfs to the setting. Playable Factions include the High Elves, the Dark Elves, the Lizardmen, and the Skaven. The second of the trilogy is set in the New World and focuses on the factions of the setting warring against each other for control over the Vortex, as well as to further their own various goals. The core gameplay remains relatively unchanged from the first game (functioning more like a massive Expansion Pack then a true sequel), but it contains several new features besides additional races, such as Rites powerful spells unique to each faction, activatable on the campaign map that provide a myriad of special boons both for the campaign and the battlefield, story focused campaigns for each race centered on the vortex, several new battlefield types, and a host of other changes that improve on the game that came before it. Six races, six outcomes, a single goal: control of the magics of the world, for good or ill. for the Star-Metal Harpoon lies in the deeps, a weapon powerful enough to bring the greatest Merwyrm of them all to heel! In the vast sandy expanses of Nehekhara, the Tomb Kings awaken once more from their deep slumber, rising from dry crypts with Settra The Imperishable in the lead to secure their dominance once and for all by going on a quest to find the missing books of Nagash The Undying.Īcross the misty seas and the salty ports of Eastern Lustria, The Undead Pirates of The Vampire Coast have had enough of simple plunder and pillaging of the ships and boats sailing the oceans, leading Arch Grand Commodore Luthor Harkon to search for more than mere treasure. Meanwhile in the Under-Empire that spans across the world, The Skaven have sent forth Queek Headtaker for a diabolical quest to gather warpstone, all in an attempt to gain control of the vortex in the name of the Horned Rat and the Council of Thirteen. He tastes great weakness in the vortex and great opportunity in its demise. The Witch King Malekith and his sadistic Dark Elf hordes spew forth from Naggaroth and their labyrinthine Black Arks. He, too, is intent on preventing cataclysm, though the methods of The Old Ones must prevail. Prince Tyrion, Defender of Ulthuan, guides the High Elves in their desperate efforts to stabilise the vortex as it roils above their home continent.Ītop his palanquin-throne, the Slann Mage-Priest Mazdamundi directs his Lizardmen war-hosts as they surge northward from Lustria. The race is on, and the very fate of the world will lie in the hands of the victor. Yet others seek to harness its terrible energies for their own bitter purpose. Powerful forces move to heal the maelstrom and avert catastrophe. Now the Great Vortex falters, and the world again stands at the brink of ruin. Its purpose was to draw the Winds of Magic from the world as a sinkhole drains an ocean, and blast the Daemonic hordes back to the Realm of Chaos. Millennia ago, besieged by a Chaos invasion, a conclave of High Elf mages forged a vast, arcane vortex. Players who own both games, as well as individual DLC packs, will have the option of playing them separately or as a single combined campaign map, the massive Mortal Empires campaign. It is to take place in the New World, Ulthuan and the Southlands, and will focus one the Vortex in Ulthuan, a maelstrom of arcane energies created by High Elf mages to drain excess magic and Chaos influence from the material world, and the playable races' struggle to control both it and the Ley Line network in Lustria. The game was announced on Ma, confirmed for release later that year with the introduction of the Dark Elves, High Elves, Lizardmen and Skaven. Total War: Warhammer II is the sequel to Total War: Warhammer and the second game in the planned trilogy. ![]() ![]() ![]() What isn't: the impact of this attack on Gawker. Thiel's level of involvement in each of these initiatives remains opaque. And at least one Silicon Valley billionaire has quietly pursued the concept of a Gawker buyout by indirectly reaching out to former staffers. ![]() Some in the Los Angeles legal community talk openly about a coordinated strategy against Gawker. Specifically, while Gawker has found itself defending numerous Thiel-backed lawsuits attacking its kind of journalism, there has also been an orchestrated effort to initiate a class-action labor suit against it. Rather than simply play the vigilante, available to help those who have been publicly attacked by a company even the most ardent press advocates must hold their noses to defend, Thiel secretly declared a multi-front war against Gawker, seeking to crush it by any means necessary. But over the past two weeks, which has included interviews with more than 50 people, FORBES has pieced together the kind of narrative that a site like Gawker used to feast on. Thiel has been deliberately vague, granting just one interview-to The New York Times -and refusing to talk to FORBES about this subject. Thiel, lauded by a host of other Silicon Valley heavy hitters who have felt Gawker's wrath, from Chris Sacca to Vinod Khosla, has described his efforts as "one of my greater philanthropic things," helping those who have been wronged by a "singularly terrible bully." Gawker, supported by free-speech advocates like eBay founder Pierre Omidyar and Amazon CEO Jeff Bezos, has denounced Thiel's gambit as an attempt to permanently snuff out an unpopular media outlet through aggressive litigation. The revelation that Thiel paid Hogan's lawyers-to the tune of about $10 million-has transformed that discussion. The most damaging lawsuit-an invasion-of-privacy case revolving around a sex tape of the wrestler Hulk Hogan (real name, Terry Bollea)-recently resulted in a $140 million jury award and a national debate on the rights of celebrities versus the rights of a publication to disseminate what it considers to be newsworthy. Towering over them all: a 12-story banner extolling HBO's Silicon Valley, which lampoons the culture and excesses of America's technology industry.Īnd lording over that advertisement: the Hollywood Hills mansion of billionaire Peter Thiel, an early Facebook investor who also inspired one of the HBO show's most incisive characters, Peter Gregory, a mix of awkward eccentricity and reserved ruthlessness.Īs the past few weeks have shown, the real Thiel is even more eccentric and ruthless than his fictional alter ego.Īs FORBES revealed in late May, Thiel is the clandestine financier of numerous lawsuits targeting Gawker Media, the New York-based company whose biting style of journalism has grated on the egos and sullied the reputations of some of the world's most powerful people. Hollywood's elite driving down Sunset Boulevard are first beckoned to support Netflix's Jessica Jones. The result was both condemned by advocates of press freedom and praised by those who deemed the decision as a blow against press intrusion.Īs yet, there’s no word on who could play Bollea in the movie.It's voting season for the Emmy Awards, which means that electioneering in the form of billboards rising into the haze dominates the Los Angeles skyline. Peter Thiel, the billionaire behind Paypal, helped to fund the lawsuit, said to be in retaliation for the site outing him in 2007.įollowing a two week trial, it was ruled that the site would pay Bollea $115 million in damages, which eventually resulted in Gawker Media going bust in 2016. The former wrestler, real name Terry Gene Bollea, sued Gawker Media after it posted parts of a sex tape on its site in 2012. ![]() The movie will follow the events detailed in the book Conspiracy: Peter Thiel, Hulk Hogan, Gawker, And The Anatomy of Intrigue, with Charles Randolph, who penned The Big Short, on adaptation duties. ![]() The Hulk Hogan lawsuit that caused the closure of celebrity website Gawker is to be made into a movie.įrancis Lawrence, who helmed the Hunger Games movies along with recent Jennifer Lawrence movie Red Sparrow, is on board to direct. ![]() ![]() ![]() In 2020 the company, along with Zipline, Wingcopter and 7 others was selected by FAA to participate in a type certification program for delivery drones. 11. Amazon Prime Air, or simply Prime Air, is a drone delivery service currently in development by Amazon.The service uses delivery drones to autonomously fly individual packages to customers. The usual influx of library move titles this month include: Hannibal, Shutter Island, and Edward Scissorhands on Oct. That will be followed by the horrifying Run Sweetheart Run on Oct. Medieval dramedy Catherine Called Birdy premieres on Oct. October is home to a couple of Amazon movies of note as well. Last month, Amazon opened its 1.5 billion superhub at the Cincinnati/Northern Kentucky International Airport, which spans 600 acres and features an 800,000-square-foot robotic sort center, where. Amazon Air has seen rapid expansion over the past six years. This is not confirmed but has strong support and makes sense for its expansion in the region. Simple Flying looked at rumors in late 2020 that Amazon was also behind a new startup airline in Brisbane, Australia. (the devil’s hour) each night to receive a disturbing vision. Amazon Air already has its first European base in Germany. This British thriller comes form Steven Moffat and tells the story of a woman who wakes up at 3:33 a.m. The other TV series of note in October is The Devil’s Hour on Oct. Fittingly, Westworld‘s Jonathan Nolan and Lisa Joy serve as executive producers. Based on a 2014 sci-fi novel by William Gibson, The Peripheral stars Chloë Grace Moretz as a woman in a near-future society who may have just discovered an alternate reality. While not outright horror, it does sound more than a little unnerving. ![]() The biggest release this month is Prime Video original series The Peripheral on Oct. We’ve been working for almost a decade to make it a reality. The promise of drone delivery has often felt like science fiction. With its list of new releases for October 2022, Amazon Prime Video isn’t fully aboard the spooky season train but it is at least spooky adjacent. Amazon Prime Air prepares for drone deliveries Written by Amazon Staff 3 min JAmazon customers in Lockeford, California, will be among the first to receive Prime Air drone deliveries in the U.S. ![]() ![]() When I made these projects, I did run into the issues described by Leslie Peppers: several lines and characters were missing from the text of my projects in the preview window. I probably won’t be using anything but Single Line Fonts for any special writing or foiling projects in the future. Related: Watch our video tutorial of how to fill in fonts with the Design Space Offset ToolĪs you can see from both of these test projects, the writing is absolutely flawless, no gaps, no hollow spaces, no bubbling. We go this bit of advice from Leslie Peppers of Single Line Fonts: Ungroup the text, then attach the letters, and you should get a perfect result! We also had results where Design Space didn’t correctly read a letter and didn’t complete the outline of the text.Design Space will see this as a separate shape to trace. I was working with fairly small type, so I set the value to –0.02″ or –0.015″. If a second pass doesn’t work, you can use the offset function in Cricut Design Space to set an offset line inside the text!Highlight your text, click the Offset Icon in the top menu bar and set a negative value.For really fancy projects, you should consider doing this step as default step. Sometimes a second pass over the text will darken the lines enough to fill in the gaps. Try duplicating your text layer, and aligning it exactly over the original layer.But we do have other methods to get any thin font look better when drawn. ![]() As we said above, we switched to a thicker tip pen and got better results. There are a few different tricks you can try to overcome the hollow letter look. This selection of fonts is written with a Cricut 1.0 mm black pen The wider the tip of your writing tool, the thicker the line, and when your Cricut traces each letter, the thickness of the line will fill in any hollow text. Step 3: Select a thicker pen or marker to write your text. If it’s an inch tall or less, you should be able to minimize the hollow effect when Design Space outlines your letters. Step 2: Set the font size fairly small in your design. Step 1: Select thin fonts from your own collection or search for them on your favorite font sites. If you don’t have or want a Cricut Access subscription or you don’t see what you need from the portfolio above, there are other options to get great results with non-Cricut fonts. Free Alternatives to Cricut Writing Fonts If you want to be able to just select from Design Space and Make your projects quickly, having Access makes it very easy to choose a writing font that work as you expect it to. PDFs of the Cricut writing fonts are shown slightly smaller than originally written.Ĭricut Sans is a great basic font, and most of the other fonts are very lighthearted and great for casual projects. Each font name was written as either 3.25″ wide, or 0.5″ tall. The fonts that require an additional fee are shown as a screenshot, but all other fonts were written using a Cricut Fine Point (0.4mm) black pen. Instead of just taking screenshots of every font, we’ve written each font, scanned it and created a vector to give you the most accurate representation of what each font looks like on the page. If you are looking for a printable guide to all of the writing fonts available in Cricut Design Space, we’ve prepared two comprehensive PDFs that you can download, print and keep as a handy resource for your future projects. One font, BFC Bubble Baths, is designated as being licensed and so a fee is added when you go to the Make It screen – I left this font out for now, I think this is a mistake in DS. I wrote 25 of them out and added them to our Cricut Writing Font Guide. Update August 2022: 26 new writing fonts have been added to Design Space. Update April 2022: 27 new fonts have been added to Design Space, so I wrote them out and added them to the Cricut Writing Font Guide (and slideshow below). Click through the slideshow to view each category. I’ve also separated them into kerned and unkerned fonts. The fonts are categorized into “ regular style,” “ hand printed,” “ fancy hand printed,” “ handwritten/script,” and “ open/novelty” according to general visual style. There are many informal script and handwriting fonts, and even a few outline fonts. These fonts are exclusive to Cricut, so searching for them online won’t produce the results you’re looking for. ![]() Here is the full roster of Cricut writing fonts. What are all the Cricut Writing Fonts (slideshow)? For subscribers, these fonts will make it easy to add hand-lettering style fonts for cards, journaling, labels and more. ![]() When you select a Cricut writing font, the default line type will be pen, although you can change it to foil without altering the appearance.Īs noted above, these fonts are included in Cricut Access subscriptions. ![]() ![]() ![]() ![]() ![]() Libraries Skills: Access, Academic Libraries, Information Literacy, Public Libraries, Higher Education, Research, Library, Digital Libraries, Library Research, Social Networking, Social Media, Community Outreach, Microsoft Office, Art History, History, Cultural Heritage, Teaching, Library Science, Volunteer Management, Collection Development, Historic Preservation, Books, Editing, Archives, Blogging, Art, Creative Writing, Historical Research, Photography, Digitization, Nonprofits, Architectural History, Museum Education, Cultural Resource., Anthropology, Curating, Historical., Libraries Education: University of Kent at Canterbury 2003 – 2004 History Indiana University Purdue University 2002 – 2004 Ball State University (BSU) Muncie Central High Experience: Muncie Public Library August 2015 – Present Muncie Public Library September 2014 – August 2015 Whitely Community Council 2015 – 2015 Ball State University July 2010 – August 2014 Blogging 2012 – 2013 Independent Contractor February 2011 – September 2012 Ivy Tech Community College July 2008 – July 2010 Indianapolis Marion County Public Library February 2003 – May 2003 Muncie Public Library January 1998 – January 2002 Show moreįinancial Treatment Plans For SoCal Physiciansįinancial Services Skills: Investments, Portfolio Management, Financial Modeling, Asset Management, Due Diligence, Financial Analysis, Valuation, Business Analysis, Private Equity, Risk Management, Financial Planning, Financial Services, Finance, Personal Finance, Personal Financial., Investment Strategies, Behavioral Finance, Financial Advisory Education: UCLA Anderson School of Management 2008 – 2010 MBA, Finance and Real Estate University of Southern California 1997 – 1999 Master of Science (MS), Computer Science Experience: Qubera Wealth Management Inc March 2012 – Present Stansberry Research November 2010 – December 2011 OneWest Bank May 2010 – October 2010 Marcus & Millichap June 2009 – September 2009 MarketPsy Capital January 2009 – July 2009 Forecast Investments March 2005 – June 2007 Linspire Inc February 2002 – February 2006 Akamai Technologies July 1999 – December 2001 Show moreĭirector of Business Development at SalusTelehealth International Partnership Stay tuned for the next podcasts in the season.County Records Scanner/Indexer Local History and Genealogy at Muncie Public Library Thank you, Andreas and the team at HotSwitch for your insights! Using a mobile or web platform to allow fans to engage in chat, polls, trivia, and more. They will interact with TV stations as a service. ![]() In this episode of season seven, it is our pleasure to introduce you to Andres Aranguibel and the people behind HotSwitch, an early-stage start-up that is part of the third cohort in the accelerator promoted and supported by Startupbootcamp. ![]() ![]() ![]() mudah-mudahan isi postingan Artikel Sport Offline, yang kami tulis ini dapat anda pahami. You can also take over your favourite team as a manager and lead it to glory, or replay the best games of the past by entering History mode.Ĭompatible devices List: Having android 2.1 & Up. Real Football 2011 apk + data - Hallo sahabat Download Game, Pada Artikel yang anda baca kali ini dengan judul Real Football 2011 apk + data, kami telah mempersiapkan artikel ini dengan baik untuk anda baca dan ambil informasi didalamnya. Online updates of the database will keep your game up to date with the most recent player transfers and lineup changes.Īccess many different game modes including Exhibition, League and various International Cup modes, or practise your skills in Training mode. Thousands of real players’ names, 350 teams and 14 league championships to play including England, Spain, France, Germany and South America. New effects and cutscenes during the games for an even more TV-like football experience. Smarter moves for your teammates and opponents on the field thanks to an improved AI. Over 700 motion-capture-based animations that adjust to players’ skills and positions on the field. ![]() Send your comments, interact with friends, upload pictures and videos.Įnjoy smoother and more realistic graphics for both players and stadiums. Get the latest football news thanks to official RSS feeds from, as.com and. THE BIGGEST, MOST ENJOYABLE FOOTBALL COMMUNITY Ever wish you could control the outcome of a game you watched on TV? Now you can, thanks to Hypergame technology! With just the press of a button, you can recreate any match-up from the in-game news feed and play!Ĭreate your own custom team jerseys, shorts and more using a detailed editor, then share it with the rest of the community, or look for cool designs made by other players and use them yourself. ![]() |
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